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KMID : 1134820180470070697
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Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 7 p.697 ~ p.702
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Histidine Suppresses IgE-Mediated Allergic Responses
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Silwal Prashanta
Choi Seul-Gi
Shin Keun-A
Lee Chan-Yong
Park Jong-Il
Heo Jun-Young
Im Kyu
Park Seung-Gil
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Abstract
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Mast cells are major immune cells in allergies that secrete allergic mediators in response to antigen stimulation. The amino acid, histidine, ameliorates the inflammation that mast cells are involved. On the other hand, there are no reports of the effects of histidine on the activation of mast cells. This study examined the anti-allergic effects of histidine with well-established experimental methods in allergy studies, including IgE-mediated passive cutaneous anaphylaxis (PCA) in mice and mast cell activation responses, such as degranulation, secretion of inflammatory lipid LTB4 and cytokines (TNF-α and IL-4). The intraperitoneal administration of 100 mg/kg histidine suppressed PCA significantly (P<0.05) in mice. In addition, histidine inhibited IgE-mediated mast cell activation, including degranulation and the production of LTB4 and the inflammatory cytokines, TNF-α and IL-4. Overall, histidine suppressed the IgE-mediated allergic responses in vivo and in vitro. Histidine supplementation is expected to beneficial for IgE-mediated allergies.
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KEYWORD
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histidine, allergy, passive cutaneous anaphylaxis, mast cells, cytokines
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